Preparation and evaluation of PEG-coated zein nanoparticles for oral drug delivery purposes
نویسندگان
چکیده
Abstract The aim was to produce PEG-coated nanoparticles (NP-PEG), with mucus-permeating properties, for oral drug delivery purposes by using simple procedures and regulatory-approved compounds in order facilitate a potential clinical development. For this purpose, zein were prepared desolvation and, then, coated incubation PEG 35,000. resulting nanocarriers displayed mean size of about 200 nm negative zeta potential. presence on the surface evidenced electron microscopy confirmed FTIR analysis. Likely, hydrophobic (NP) significantly reduce their coating PEG. This increase hydrophilicity associated an important mobility pig intestinal mucus. In laboratory animals, NP-PEG (fluorescently labelled Lumogen® Red 305) different behavior when compared bare nanoparticles. After administration, NP appeared be trapped mucus mesh, whereas capable crossing protective layer reach epithelium. Finally, nanoparticles, reproducible method without employing reactive reagents, may adequate carriers promoting bioavailability biomacromolecules other biologically active low permeability properties.
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2021
ISSN: ['0378-5173', '1873-3476']
DOI: https://doi.org/10.1016/j.ijpharm.2021.120287